Exocrine Pancreas

Matthew A. Wallig, John M. Sullivan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The exocrine pancreas secretes digestive enzymes into the small intestine and provides a microenvironment for pancreatic islet cells that modulate blood glucose (among other functions). The exocrine pancreas is seldom a prominent target of acute or xenobiotic-induced toxicity in spite of several key observations: close proximity to the small intestine and potentially toxic ingesta; unique function in producing most digestive enzymes; proximity to the common bile duct, bile salts, and acids that could inappropriately activate digestive enzymes; and complexity of the organ, with prominent colocated endocrine and exocrine components. Epidemiologically, pancreatic injury has been associated with both a range of environmental pollutants and consumption of mycotoxins, and has long-standing links to alcoholism and smoking tobacco in humans.

Original languageEnglish (US)
Title of host publicationFundamentals of Toxicologic Pathology
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
Pages443-458
Number of pages16
ISBN (Electronic)9780128098424
ISBN (Print)9780128098417
DOIs
StatePublished - Jan 1 2018

Keywords

  • Acute pancreatitis
  • Amylase
  • Apoptosis
  • Autophagic vacuoles
  • Autophagy
  • Carboxypeptidase B activation peptide (CAPAP)
  • Centroacinar cells
  • Cholecystokinin (CCK)
  • Chronic pancreatitis
  • Hyperstimulation
  • Lipase
  • Necrosis
  • Oxidant stress
  • Pancreatic acinar cells
  • Pancreatic duct cells
  • Pancreatic stellate cells
  • Secretin
  • Trypsin-like immunoreactivity (TLI)
  • Trypsinogen-activated peptide (TAP)
  • Zymogen

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Wallig, M. A., & Sullivan, J. M. (2018). Exocrine Pancreas. In Fundamentals of Toxicologic Pathology: Third Edition (pp. 443-458). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809841-7.00016-2