Exocrine Pancreas

Matthew A. Wallig, John M. Sullivan

Research output: Chapter in Book/Report/Conference proceedingChapter


The exocrine pancreas secretes digestive enzymes into the small intestine and provides a microenvironment for pancreatic islet cells that modulate blood glucose (among other functions). The exocrine pancreas is seldom a prominent target of acute or xenobiotic-induced toxicity in spite of several key observations: close proximity to the small intestine and potentially toxic ingesta; unique function in producing most digestive enzymes; proximity to the common bile duct, bile salts, and acids that could inappropriately activate digestive enzymes; and complexity of the organ, with prominent colocated endocrine and exocrine components. Epidemiologically, pancreatic injury has been associated with both a range of environmental pollutants and consumption of mycotoxins, and has long-standing links to alcoholism and smoking tobacco in humans.

Original languageEnglish (US)
Title of host publicationFundamentals of Toxicologic Pathology
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128098424
ISBN (Print)9780128098417
StatePublished - Jan 1 2018


  • Acute pancreatitis
  • Amylase
  • Apoptosis
  • Autophagic vacuoles
  • Autophagy
  • Carboxypeptidase B activation peptide (CAPAP)
  • Centroacinar cells
  • Cholecystokinin (CCK)
  • Chronic pancreatitis
  • Hyperstimulation
  • Lipase
  • Necrosis
  • Oxidant stress
  • Pancreatic acinar cells
  • Pancreatic duct cells
  • Pancreatic stellate cells
  • Secretin
  • Trypsin-like immunoreactivity (TLI)
  • Trypsinogen-activated peptide (TAP)
  • Zymogen

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Wallig, M. A., & Sullivan, J. M. (2018). Exocrine Pancreas. In Fundamentals of Toxicologic Pathology: Third Edition (pp. 443-458). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809841-7.00016-2