Exercising away the blues: Can it help multiple sclerosis-related depression?

Anthony Feinstein, Neil Rector, Robert Motl

Research output: Contribution to journalReview articlepeer-review


The present review focuses on exercise as a treatment for depression in multiple sclerosis. While exercise has emerged as a potentially useful treatment in the general psychiatry-depression literature, the findings from a small number of multiple sclerosis-related treatment trials are equivocal. Methodological limitations, including the absence of depression as a primary endpoint, characterize all the studies completed to date. Given that limitations in study design can be rectified, it is time to put exercise to the test once more. Depressed multiple sclerosis patients and those involved in their care are looking for guidance here because the prevailing zeitgeist promotes the benefits of exercise to mood. But first, some clarity is needed.

Original languageEnglish (US)
Pages (from-to)1815-1819
Number of pages5
JournalMultiple Sclerosis Journal
Issue number14
StatePublished - Dec 2013


  • Depression
  • exercise
  • medication
  • multiple sclerosis
  • treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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