Exercise, Inflammation, and Innate Immunity

Jeffrey A. Woods, Victoria J. Vieira, K. Todd Keylock

Research output: Contribution to journalReview articlepeer-review


Exercise has beneficial effects on chronic disease, and the drive to understand the mechanisms of these benefits is strong. This article presents several compelling potential mechanisms for the anti-inflammatory effect of exercise, including reduced percentage of body fat and macrophage accumulation in adipose tissue, muscle-released interleukin-6 inhibition of tumor necrosis factor-a, and the cholinergic anti-inflammatory pathway.

Original languageEnglish (US)
Pages (from-to)381-393
Number of pages13
JournalImmunology and Allergy Clinics of North America
Issue number2
StatePublished - May 1 2009


  • Exercise
  • Innate immunity
  • Macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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