Exercise-induced modulation of macrophage function

J. A. Woods, Q. Lu, M. A. Ceddia, T. Lowder

Research output: Contribution to journalReview article

Abstract

Macrophages are important effector cells involved in phagocytosis, microbial killing and antitumour activity. Macrophages also display accessory cell function, in that they can present antigen to foster the development oft lymphocyte-mediated immunity. Recent work, including studies from this group, has demonstrated that acute and chronic exercise can affect many facets of macrophage biology. Manifestation of these effects depends on exercise intensity and duration, the function measured, the timing of measurement in relation to exercise and the concentration of the macrophage-activating stimulus. Exercise has potent stimulatory effects on phagocytosis, antitumour activity, reactive oxygen and nitrogen metabolism, and chemotaxis. Indeed, it has been shown that exercise training can increase macrophage antitumour activity in mice of different ages. However, not all functions are enhanced by exercise. Exercise-induced reductions in macrophage MHC II expression and antigen-presentation capacity have been documented. These findings bring up the possibility that exercise, and perhaps other stressors, activate macrophages for effector functions while downregulating accessory cell functions. To a large extent, the mechanisms responsible for the exercise-induced changes in macrophage function remain unknown, but may depend on exercise-induced changes in neuroendocrine factors. Future studies need to explore the effects in a mechanistic way and provide documentation as to their physiological significance.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalImmunology and Cell Biology
Volume78
Issue number5
DOIs
StatePublished - Jan 1 2000

Fingerprint

Macrophages
Phagocytosis
Exercise
Antigen Presentation
Chemotaxis
Documentation
Immunity
Nitrogen
Down-Regulation
Lymphocytes
Oxygen
Antigens

Keywords

  • Ageing
  • Exercise
  • Immune function
  • Macrophage
  • Stress
  • Training

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Exercise-induced modulation of macrophage function. / Woods, J. A.; Lu, Q.; Ceddia, M. A.; Lowder, T.

In: Immunology and Cell Biology, Vol. 78, No. 5, 01.01.2000, p. 545-553.

Research output: Contribution to journalReview article

Woods, J. A. ; Lu, Q. ; Ceddia, M. A. ; Lowder, T. / Exercise-induced modulation of macrophage function. In: Immunology and Cell Biology. 2000 ; Vol. 78, No. 5. pp. 545-553.
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