Exercise and the Regulation of Inflammatory Responses

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Exercise initiates a cascade of inflammatory events, which ultimately lead to long-term effects on human health. During and after acute exercise in skeletal muscle, interactions between immune cells, cytokines, and other intracellular components, create an inflammatory milieu responsible for the recovery and adaption from an exercise bout. In the systemic circulation, cytokines released from muscle (myokines) mediate metabolic and inflammatory processes. Moderate exercise training results in improvements in systemic inflammation, evident by reductions in acute phase proteins. The anti-inflammatory effects of regular exercise include actions dependent and independent of changes in adipose tissue mass. Future research should encompass approaches, which attempt to integrate other, less-recognized physiological processes with acute and long-term inflammatory changes. This will include investigation into metabolic, endocrine, and immune components of various tissues and organs.

Original languageEnglish (US)
Title of host publicationMolecular and Cellular Regulation of Adaptation to Exercise, 2015
EditorsClaude Bouchard
PublisherElsevier B.V.
Number of pages18
ISBN (Print)9780128039915
StatePublished - 2015

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814


  • Cytokines
  • Inflammation
  • Leukocytes
  • Macrophage
  • Repair
  • Toll-like receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


Dive into the research topics of 'Exercise and the Regulation of Inflammatory Responses'. Together they form a unique fingerprint.

Cite this