Exercise and Stem Cells

Marni D. Boppart, Michael De Lisio, Sarah Witkowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stem cells are traditionally studied in the context of embryonic development, yet studies confirm that a fraction remains in the adult organism for the purpose of daily remodeling and rejuvenation of multiple tissues following injury. Adult stem cells (ASCs) are found in close proximity to vessels and respond to tissue-specific cues in the microenvironment that dictate their fate and function. Exercise can dramatically alter strain sensing, extracellular matrix composition, and inflammation, and such changes in the niche likely alter ASC quantity and function postexercise. The field of stem cell biology is still in its infancy and identification and terminology of ASCs continues to evolve; thus, current information regarding exercise and stem cells is lacking. This chapter summarizes the literature that reports on the ASC response to acute exercise and exercise training, with particular emphasis on hematopoietic stem cells, endothelial progenitor cells, and mesenchymal stem cells.

Original languageEnglish (US)
Title of host publicationMolecular and Cellular Regulation of Adaptation to Exercise, 2015
EditorsClaude Bouchard
PublisherElsevier B.V.
Pages423-456
Number of pages34
ISBN (Print)9780128039915
DOIs
StatePublished - Jan 1 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume135
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

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Keywords

  • Circulating angiogenic cells
  • Eccentric exercise
  • Endothelial progenitor cells
  • Fibro/adipogenic progenitors
  • Hematopoietic stem cells
  • Mesenchymal stem cells
  • Multipotent stem cells
  • Pericytes
  • SP cells
  • Satellite cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Boppart, M. D., De Lisio, M., & Witkowski, S. (2015). Exercise and Stem Cells. In C. Bouchard (Ed.), Molecular and Cellular Regulation of Adaptation to Exercise, 2015 (pp. 423-456). (Progress in Molecular Biology and Translational Science; Vol. 135). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2015.07.005