Exercise and hematopoietic stem and progenitor cells: Protection, quantity, and function

Michael De Lisio, Gianni Parise

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of exercise on mature cells of the hematopoietic lineage have been well characterized; however, the effects of exercise on the more primitive cells of the hematopoietic system are unknown. Here, we propose that the benefits of exercise apply to hematopoietic progenitors and that exercise increases hematopoietic stem cell quantity primarily mediated via adaptations in the stem cell niche.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalExercise and Sport Sciences Reviews
Volume41
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • bone marrow transplantation
  • exercise
  • exercise training
  • hematopoietic stem cell
  • hormesis
  • niche
  • radioprotection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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