Exercise and gut immune function

Evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training

Marc D. Cook, Jacob M. Allen, Brandt D. Pence, Matthew A. Wallig, H. Rex Gaskins, Bryan A. White, Jeffrey A. Woods

Research output: Contribution to journalReview article

Abstract

There is robust evidence that habitual physical activity is anti-inflammatory and protective against developing chronic inflammatory disease. Much less is known about the effects of habitual moderate exercise in the gut, the compartment that has the greatest immunological responsibility and interactions with the intestinal microbiota. The link between the two has become evident, as recent studies have linked intestinal dysbiosis, or the disproportionate balance of beneficial to pathogenic microbes, with increased inflammatory disease susceptibility. Limited animal and human research findings imply that exercise may have a beneficial role in preventing and ameliorating such diseases by having an effect on gut immune function and, recently, microbiome characteristics. Emerging data from our laboratory show that different forms of exercise training differentially impact the severity of intestinal inflammation during an inflammatory insult (for example, ulcerative colitis) and may be jointly related to gut immune cell homeostasis and microbiota-immune interactions. The evidence we review and present will provide data in support of rigorous investigations concerning the effects of habitual exercise on gut health and disease.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalImmunology and Cell Biology
Volume94
Issue number2
DOIs
StatePublished - Feb 1 2016

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Microbiota
Colon
Homeostasis
Dysbiosis
Exercise
Disease Susceptibility
Ulcerative Colitis
Chronic Disease
Anti-Inflammatory Agents
Inflammation
Health
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Exercise and gut immune function : Evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training. / Cook, Marc D.; Allen, Jacob M.; Pence, Brandt D.; Wallig, Matthew A.; Gaskins, H. Rex; White, Bryan A.; Woods, Jeffrey A.

In: Immunology and Cell Biology, Vol. 94, No. 2, 01.02.2016, p. 158-163.

Research output: Contribution to journalReview article

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