TY - JOUR
T1 - Examining the association between prenatal maternal stress and infant non-nutritive suck
AU - on behalf of Program Collaborators for Environmental Influences on Child Health Outcomes
AU - Zimmerman, Emily
AU - Aguiar, Andrea
AU - Aung, Max T.
AU - Geiger, Sarah Dee
AU - Hines, Morgan
AU - Woodbury, Megan L.
AU - Martens, Alaina
AU - Huerta-Montanez, Gredia
AU - Cordero, José F.
AU - Meeker, John D.
AU - Schantz, Susan L.
AU - Alshawabkeh, Akram N.
N1 - Funding Information:
Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), and U2COD023375 (OIF). Dr. Aung’s work was supported by NIH award number P30ES030284. Research on the ECHO-PROTECT cohort was supported by the Children’s Environmental Health and Disease Prevention Research Center (NNIEHS P42ES017198, P50ES026049, and UH3OD023251), the Environmental Protection Agency (EPA) grant R836155, the Environmental Influences on Child Health Outcomes (ECHO) Program (NIH OD023251), and the National Institute on Minority Health and Health Disparities, award number U54MD007600. Research on the IKIDS cohort was supported by the Children’s Environmental Health and Disease Prevention Research Center (NIEHS P01 ES022848 and USEPA RD83543401) and the ECHO Program (NIH OD023272).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
PY - 2023/4
Y1 - 2023/4
N2 - Background: This study examined the relationship between prenatal maternal stress (PREMS) and non-nutritive suck (NNS) and tested its robustness across 2 demographically diverse populations. Methods: The study involved 2 prospective birth cohorts participating in the national Environmental influences on Child Health Outcomes (ECHO) Program: Illinois Kids Development Study (IKIDS) and ECHO Puerto Rico (ECHO-PROTECT). PREMS was measured during late pregnancy via the 10-item Perceived Stress Scale (PSS-10). NNS was sampled from 1- to 8-week-olds using a custom pacifier for ~5 min. Results: Overall, 237 mother–infant dyads completed this study. Despite several significant differences, including race/ethnicity, income, education, and PREMS levels, significant PREMS-NNS associations were found in the 2 cohorts. In adjusted linear regression models, higher PREMS, measured through PSS-10 total scores, related to fewer but longer NNS bursts per minute. Conclusions: A significant association was observed between PREMS and NNS across two diverse cohorts. This finding is important as it may enable the earlier detection of exposure-related deficits and, as a result, earlier intervention, which potentially can optimize outcomes. More research is needed to understand how NNS affects children’s neurofunction and development. Impact: In this double-cohort study, we found that higher maternal perceived stress assessed in late pregnancy was significantly associated with fewer but longer sucking bursts in 1- to 8-week-old infants.This is the first study investigating the association between prenatal maternal stress (PREMS) and infant non-nutritive suck (NNS), an early indicator of central nervous system integrity.Non-nutritive suck is a potential marker of increased prenatal stress in diverse populations.Non-nutritive suck can potentially serve as an early indicator of exposure-related neuropsychological deficits allowing for earlier interventions and thus better prognoses.
AB - Background: This study examined the relationship between prenatal maternal stress (PREMS) and non-nutritive suck (NNS) and tested its robustness across 2 demographically diverse populations. Methods: The study involved 2 prospective birth cohorts participating in the national Environmental influences on Child Health Outcomes (ECHO) Program: Illinois Kids Development Study (IKIDS) and ECHO Puerto Rico (ECHO-PROTECT). PREMS was measured during late pregnancy via the 10-item Perceived Stress Scale (PSS-10). NNS was sampled from 1- to 8-week-olds using a custom pacifier for ~5 min. Results: Overall, 237 mother–infant dyads completed this study. Despite several significant differences, including race/ethnicity, income, education, and PREMS levels, significant PREMS-NNS associations were found in the 2 cohorts. In adjusted linear regression models, higher PREMS, measured through PSS-10 total scores, related to fewer but longer NNS bursts per minute. Conclusions: A significant association was observed between PREMS and NNS across two diverse cohorts. This finding is important as it may enable the earlier detection of exposure-related deficits and, as a result, earlier intervention, which potentially can optimize outcomes. More research is needed to understand how NNS affects children’s neurofunction and development. Impact: In this double-cohort study, we found that higher maternal perceived stress assessed in late pregnancy was significantly associated with fewer but longer sucking bursts in 1- to 8-week-old infants.This is the first study investigating the association between prenatal maternal stress (PREMS) and infant non-nutritive suck (NNS), an early indicator of central nervous system integrity.Non-nutritive suck is a potential marker of increased prenatal stress in diverse populations.Non-nutritive suck can potentially serve as an early indicator of exposure-related neuropsychological deficits allowing for earlier interventions and thus better prognoses.
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U2 - 10.1038/s41390-021-01894-9
DO - 10.1038/s41390-021-01894-9
M3 - Article
C2 - 34916626
AN - SCOPUS:85121340547
SN - 0031-3998
VL - 93
SP - 1285
EP - 1293
JO - Pediatric Research
JF - Pediatric Research
IS - 5
ER -