Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR

Kristof Grohe; Evgeny Nimerovsky; Himanshu Singh; Suresh K. Vasa; Benedikt Söldner; Beat Vögeli; Chad M. Rienstra; Rasmus Linser

doi:10.1039/c9cc02317h

Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR

Kristof Grohe, Evgeny Nimerovsky, Himanshu Singh, Suresh K. Vasa, Benedikt Söldner, Beat Vögeli, Chad M. Rienstra, Rasmus Linser

Research output: Contribution to journal › Article › peer-review

Abstract

Fast-magic-angle-spinning solid-state NMR is a developing technique for determination of protein structure and dynamics. Proton-proton correlations usually lead to rough distance restraints, a serious hurdle towards high-resolution structures. Analogous to the "eNOE" concept in solution, an integrative approach for more accurate restraints enables improved structural accuracy with minimal analytical effort.

Original language	English (US)
Pages (from-to)	7899-7902
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	55
DOIs	https://doi.org/10.1039/c9cc02317h
State	Published - 2019

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c9cc02317h

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T1 - Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR

AU - Grohe, Kristof

AU - Nimerovsky, Evgeny

AU - Singh, Himanshu

AU - Vasa, Suresh K.

AU - Söldner, Benedikt

AU - Vögeli, Beat

AU - Rienstra, Chad M.

AU - Linser, Rasmus

PY - 2019

Y1 - 2019

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AB - Fast-magic-angle-spinning solid-state NMR is a developing technique for determination of protein structure and dynamics. Proton-proton correlations usually lead to rough distance restraints, a serious hurdle towards high-resolution structures. Analogous to the "eNOE" concept in solution, an integrative approach for more accurate restraints enables improved structural accuracy with minimal analytical effort.

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JO - Chemical Communications

JF - Chemical Communications

IS - 55

ER -

Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR

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