The anti-inflammatory cytokine interleukin (IL)-10 is important for regulating inflammation in the periphery and brain, but whether it protects against infection- or age-related psychomotor disturbances and fatigue is unknown. Therefore, the present study evaluated motor coordination, time to fatigue, and several central and peripheral proinflammatory cytokines in male young adult (3-mo-old) and middle-aged (12-mo-old) wild-type (IL-10 +/+) and IL-10-deficient (IL-10-/-) mice after intraperitoneal injection of lipopolysaccharide (LPS) or saline. No age-related differences were observed; therefore, data from the two ages were pooled and analyzed to determine effects of genotype and treatment. LPS treatment increased IL-1β, IL-6, and TNFα mRNA in all brain areas examined in IL-10 +/+ and IL-10-/- mice, but to a greater extent and for a longer time in IL-10-/- mice. Plasma IL-1β and IL-6 were increased similarly in IL-10+/+ and IL-10-/- mice 4 h after LPS but remained elevated longer in IL-10-/- mice, whereas TNFα was higher in IL-10-/- mice throughout after LPS treatment. Motor performance and motor learning in IL-10+/+ mice were not affected by LPS treatment; however, both were reduced in IL-10 -/- mice treated with LPS compared with those treated with saline. Furthermore, although LPS reduced the time to fatigue in IL-10+/+ and IL-10-/- mice, the effects were exacerbated in IL-10-/- mice. Thus the increased brain and peripheral inflammation induced by LPS in IL-10-/- mice was associated with increased coordination deficits and fatigue. These data suggest that IL-10 may inhibit motor deficits and fatigue associated with peripheral infections via its anti-inflammatory effects.
|Original language||English (US)|
|Journal||American Journal of Physiology - Regulatory Integrative and Comparative Physiology|
|State||Published - Oct 2008|
- Motor coordination
- Proinflammatory cytokines
ASJC Scopus subject areas
- Physiology (medical)