Evolution of the diverse antifreeze proteins

Research output: Contribution to journalArticlepeer-review


Different types of ice-growth-inhibiting antifreeze proteins, first recognized in fish, have now been isolated from insects and plants, and the list continues to expand. Their structures are amazingly diverse; how they attain the same function are subjects of intense research. Evolutionary precursors of several members have been identified - divergent proteins of apparently unrelated function. The hybridization of information from structural and molecular evolution studies of these molecules provides a forum in which issues of selection, gene genealogy, adaptive evolution, and invention of a novel function can be coherently addressed.

Original languageEnglish (US)
Pages (from-to)715-720
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 1998

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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