Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes

Sanjaya C. Abeysirigunawardena; Hajin Kim; Jonathan Lai; Kaushik Ragunathan; Mollie C. Rappé; Zaida Luthey-Schulten; Taekjip Ha; Sarah A. Woodson

doi:10.1038/s41467-017-00536-1

Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes

Sanjaya C. Abeysirigunawardena, Hajin Kim, Jonathan Lai, Kaushik Ragunathan, Mollie C. Rappé, Zaida Luthey-Schulten, Taekjip Ha, Sarah A. Woodson

Research output: Contribution to journal › Article › peer-review

Abstract

Ribosomes assemble through the hierarchical addition of proteins to a ribosomal RNA scaffold. Here the authors use three-color single-molecule FRET to show how the dynamics of the rRNA dictate the order in which multiple proteins assemble on the 5′ domain of the E. coli 16S rRNA.

Original language	English (US)
Article number	492
Journal	Nature communications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-00536-1
State	Published - Dec 1 2017

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-017-00536-1

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AU - Abeysirigunawardena, Sanjaya C.

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AU - Rappé, Mollie C.

AU - Luthey-Schulten, Zaida

AU - Ha, Taekjip

AU - Woodson, Sarah A.

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Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes

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