Evolution of function in (β/α)8-barrel enzymes

John A. Gerlt, Frank M. Raushel

Research output: Contribution to journalReview articlepeer-review


The (β/α)8-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (β/α)8-barrel containing enzymes.

Original languageEnglish (US)
Pages (from-to)252-264
Number of pages13
JournalCurrent Opinion in Chemical Biology
Issue number2
StatePublished - Apr 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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