Evolution of function in (β/α)8-barrel enzymes

John A. Gerlt; Frank M. Raushel

doi:10.1016/S1367-5931(03)00019-X

Evolution of function in (β/α)₈-barrel enzymes

Research output: Contribution to journal › Review article › peer-review

Abstract

The (β/α)₈-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (β/α)₈-barrel containing enzymes.

Original language	English (US)
Pages (from-to)	252-264
Number of pages	13
Journal	Current Opinion in Chemical Biology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S1367-5931(03)00019-X
State	Published - Apr 2003

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

Online availability

10.1016/S1367-5931(03)00019-X

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Cite this

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title = "Evolution of function in (β/α)8-barrel enzymes",

abstract = "The (β/α)8-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (β/α)8-barrel containing enzymes.",

author = "Gerlt, {John A.} and Raushel, {Frank M.}",

note = "Funding Information: The research in the authors{\textquoteright} laboratories is funded by: JAG, NIH GM-52594 and NIH GM-58506; FMR., NIH GM-33894 and Office of Naval Research (N00014-99-0235). ",

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AU - Raushel, Frank M.

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AB - The (β/α)8-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (β/α)8-barrel containing enzymes.

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