Evolution of enzyme superfamilies

Margaret E. Glasner, John Alan Gerlt, Patricia C. Babbitt

Research output: Contribution to journalReview article

Abstract

Enzyme evolution is often constrained by aspects of catalysis. Sets of homologous proteins that catalyze different overall reactions but share an aspect of catalysis, such as a common partial reaction, are called mechanistically diverse superfamilies. The common mechanistic steps and structural characteristics of several of these superfamilies, including the enolase, Nudix, amidohydrolase, and haloacid dehalogenase superfamilies have been characterized. In addition, studies of mechanistically diverse superfamilies are helping to elucidate mechanisms of functional diversification, such as catalytic promiscuity. Understanding how enzyme superfamilies evolve is vital for accurate genome annotation, predicting protein functions, and protein engineering.

Original languageEnglish (US)
Pages (from-to)492-497
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2006

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Catalysis
Amidohydrolases
Molecular Sequence Annotation
Protein Engineering
Phosphopyruvate Hydratase
Enzymes
Proteins
Genome
Genes
2-haloacid dehalogenase

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Evolution of enzyme superfamilies. / Glasner, Margaret E.; Gerlt, John Alan; Babbitt, Patricia C.

In: Current Opinion in Chemical Biology, Vol. 10, No. 5, 01.10.2006, p. 492-497.

Research output: Contribution to journalReview article

Glasner, Margaret E. ; Gerlt, John Alan ; Babbitt, Patricia C. / Evolution of enzyme superfamilies. In: Current Opinion in Chemical Biology. 2006 ; Vol. 10, No. 5. pp. 492-497.
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