Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps

William J. Murphy, Denis M. Larkin, Annelie Everts-Van Der Wind, Guillaume Bourque, Glenn Tesler, Loretta Auvil, Jonathan Edward Beever, Bhanu P. Chowdhary, Francis Galibert, Lisa Gatzke, Christophe Hitte, Stacey N. Meyers, Denis Milan, Elaine A. Ostrander, Greg Pape, Heidi G. Parker, Terje Raudsepp, Margarita B. Rogatcheva, Lawrence B Schook, Loren C. SkowMichael Welge, James E. Womack, Stephen J. O'Brien, Pavel A. Pevzner, Harris A. Lewin

Research output: Contribution to journalArticlepeer-review

Abstract

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalScience
Volume309
Issue number5734
DOIs
StatePublished - Jul 22 2005

ASJC Scopus subject areas

  • General

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