@techreport{481e830f793e4c3c90c696f3628d6f8c,
title = "Evidence of antigenic imprinting in sequential Sarbecovirus immunization",
abstract = "Antigenic imprinting, which describes the bias of antibody response due to previous immune history, can influence vaccine effectiveness and has been reported in different viruses. Give that COVID-19 vaccine development is currently a major focus of the world, there is a lack of understanding of how background immunity influence antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting in Sarbecovirus, which is the subgenus that SARS-CoV-2 belongs to. Specifically, we sequentially immunized mice with two antigenically distinct Sarbecovirus strains, namely SARS-CoV and SARS-CoV-2. We found that the neutralizing antibodies triggered by the sequentially immunization are dominantly against the one that is used for priming. Given that the impact of the background immunity on COVID-19 is still unclear, our results will provide important insights into the pathogenesis of this disease as well as COVID-19 vaccination strategy.Competing Interest StatementThe authors have declared no competing interest.",
keywords = "coronavirus, COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Novel coronavirus, 2019-nCoV, Pandemic",
author = "Huibin Lv and So, {Ray T.Y.} and Meng Yuan and Hejun Liu and Lee, {Chang-Chun D} and Yip, {Garrick K.} and Ng, {Wilson W.} and Wilson, {Ian A.} and Peiris, {Joseph Sriyal Malik} and Wu, {Nicholas C.} and Mok, {Chris Ka Pun}",
year = "2020",
month = oct,
day = "15",
doi = "10.1101/2020.10.14.339465",
language = "English (US)",
series = "bioRxiv",
publisher = "Cold Spring Harbor Laboratory Press",
address = "United States",
type = "WorkingPaper",
institution = "Cold Spring Harbor Laboratory Press",
}