Evidence for bisphenol A-induced female infertility: a review (2007–2016)

Research output: Contribution to journalReview article

Abstract

We summarized the scientific literature published from 2007 to 2016 on the potential effects of bisphenol A (BPA) on female fertility. We focused on overall fertility outcomes (e.g., ability to become pregnant, number of offspring), organs that are important for female reproduction (i.e., oviduct, uterus, ovary, hypothalamus, and pituitary), and reproductive-related processes (i.e., estrous cyclicity, implantation, and hormonal secretion). The reviewed literature indicates that BPA may be associated with infertility in women. Potential explanations for this association can be generated from experimental studies. Specifically, BPA may alter overall female reproductive capacity by affecting the morphology and function of the oviduct, uterus, ovary, and hypothalamus-pituitary-ovarian axis in animal models. In addition, BPA may disrupt estrous cyclicity and implantation. Nevertheless, further studies are needed to better understand the exact mechanisms of action and to detect potential reproductive toxicity at earlier stages.

Original languageEnglish (US)
Pages (from-to)827-856
Number of pages30
JournalFertility and Sterility
Volume106
Issue number4
DOIs
StatePublished - Sep 15 2016

Fingerprint

Female Infertility
Oviducts
Periodicity
Hypothalamus
Uterus
Fertility
Ovary
Literature
Infertility
Reproduction
Animal Models
bisphenol A

Keywords

  • Infertility
  • bisphenol A
  • female
  • hypothalamus
  • implantation
  • ovary
  • pituitary
  • uterus

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Evidence for bisphenol A-induced female infertility : a review (2007–2016). / Ziv-Gal, Ayelet; Flaws, Jodi A.

In: Fertility and Sterility, Vol. 106, No. 4, 15.09.2016, p. 827-856.

Research output: Contribution to journalReview article

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