Evaluation of ultrasound scattering models adapted for two types of scatterers to extract scatterer parameters from cell-pellet biophantoms

Ultrasound backscatter coefficient allows the evaluation of tissue microstructure parameters. Scatterer parameters are then extracted using ultrasound scattering models. It is generally difficult to correlate the scatterer parameters to tissue structures from histology, possibly because of inappropriate scattering models or the presence of multiple scatterers. In previous work, we used an adaptation of the scattering Structure Factor Model (SFM) to take into account two types of scatterers (nuclei and cells) using a combination of SFM from nuclei and SFM from cells. Our results suggested the contribution of both nuclei and cells in the scattering. The objective of this study is to explore the possibility to extract coherent scatterer parameters with scattering models taking into account two types of scatterers: the adapted SFM for two scatterers' types and the concentric sphere model.