TY - GEN
T1 - EVALUATION OF THERAPEUTIC POTENTIAL OF PTF1A ACTIVATION TO TREAT PANCREATIC CANCER USING A MICROFLUIDIC PANCREATIC ACINAR MODEL
AU - Moon, Hye Ran
AU - Venis, Stephanie M.
AU - Yang, Yi
AU - Utturkar, Sagar M.
AU - Konieczny, Stephen F.
AU - Han, Bumsoo
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Pancreatic cancer is an unmet clinical need, and effective therapeutic strategies are highly desired. This study aims to propose and evaluate a new therapeutic strategy based on the activation of the PTF1a gene in pancreatic cancer cells, using a microfluidic pancreatic cancer model. The underlying rationale is the loss of PTF1a in acinar cells drives the progression to pancreatic cancer. We first engineer pancreatic cancer cells, whose PTF1a activation is controllable, and then incorporate the cells into a microfluidic model mimicking acinar micro-anatomy. The model clearly shows that PTF1a activation can suppress the growth and invasion of cancer cells.
AB - Pancreatic cancer is an unmet clinical need, and effective therapeutic strategies are highly desired. This study aims to propose and evaluate a new therapeutic strategy based on the activation of the PTF1a gene in pancreatic cancer cells, using a microfluidic pancreatic cancer model. The underlying rationale is the loss of PTF1a in acinar cells drives the progression to pancreatic cancer. We first engineer pancreatic cancer cells, whose PTF1a activation is controllable, and then incorporate the cells into a microfluidic model mimicking acinar micro-anatomy. The model clearly shows that PTF1a activation can suppress the growth and invasion of cancer cells.
KW - microfluidic tissue model
KW - pancreatic acinus
KW - Pancreatic ductal adenocarcinoma
KW - PTF1a
UR - http://www.scopus.com/inward/record.url?scp=85137005192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137005192&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85137005192
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1
EP - 2
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -