Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis

Ana Civantos, Andrea Mesa Restrepo, Camilo Jaramillo, Alethia Barnwell, Akshath Shetty, Jean Paul Allain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Although Titanium (Ti) and its alloys are biocompatible and non-toxic, once they are inserted in the body, as any biomaterial, they can triggers an inflammatory response, which usually is orchestrated by immune cells such macrophages and dendritic cells. In some scenarios, macrophages recognize Ti implant surface as a foreign body material expressing mainly M1 phenotype (considered classically activated or pro-inflammatory phenotype) 1 . These M1 macrophages protect the body and attack the implant trying to expulse or destroy it. However, the modification of the surface properties, and indeed, the introduction of nanofeatures, may help on the integration process. Several studied have described the role of nanotopography in macropahges bevahior, promoting the expresion of M2 phenotype (referred as alternative o anti-inlflammatory phenotype) which is related to regeneration process. 2 Several surface treatments based on chemical or physical modification has been implemented to develop nanofeatures, however, the used of plasma has increased in the past decades. Here in this work we show an advanced plasma technology called Directed Irradiation synthesis (DIS) which combine energy and momentum deposition of Argon ions to induce self-organized patterns of heterogeneous nanostructures capable of enhancing the immune response of macrophages to M2 phenotype and at the same time increasing the bioactivity of the surface improving cell viability and adhesion of human cells.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Macrophages
Titanium
Titanium alloys
Irradiation
Phenotype
Cells
Plasmas
Argon
Biocompatible Materials
Bioactivity
Biomaterials
Surface Properties
Nanostructures
Surface properties
Surface treatment
Momentum
Foreign Bodies
Adhesion
Cell Adhesion
Dendritic Cells

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Civantos, A., Restrepo, A. M., Jaramillo, C., Barnwell, A., Shetty, A., & Allain, J. P. (2019). Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis. / Civantos, Ana; Restrepo, Andrea Mesa; Jaramillo, Camilo; Barnwell, Alethia; Shetty, Akshath; Allain, Jean Paul.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Civantos, A, Restrepo, AM, Jaramillo, C, Barnwell, A, Shetty, A & Allain, JP 2019, Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Civantos A, Restrepo AM, Jaramillo C, Barnwell A, Shetty A, Allain JP. Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Civantos, Ana ; Restrepo, Andrea Mesa ; Jaramillo, Camilo ; Barnwell, Alethia ; Shetty, Akshath ; Allain, Jean Paul. / Evaluation of immune response of macrophages using bioactive nanotopography surfaces on titanium alloy (Ti6al4v) designed by directed irradiation synthesis. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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