TY - JOUR
T1 - Evaluation of electrolyte concentration and pro-inflammatory and oxidative status in dogs with advanced chronic kidney disease under dietary treatment
AU - Halfen, Doris Pereira
AU - Caragelasco, Douglas Segalla
AU - De Souza Nogueira, Juliana Paschoalin
AU - Jeremias, Juliana Toloi
AU - Pedrinelli, Vivian
AU - Oba, Patrícia Massae
AU - Ruberti, Bruna
AU - Pontieri, Cristiana Fonseca Ferreira
AU - Kogika, Marcia Mery
AU - Brunetto, Marcio Antonio
N1 - Funding Information:
This research was funded by the Coordination of Superior Level State Improvement (CAPES), which provided funding to Ph.D. studentship, and Premier Pet, which provided the diet and financial support.
Publisher Copyright:
© 2019 by the authors.
PY - 2019/12/19
Y1 - 2019/12/19
N2 - An integrated study on the effect of renal diet on mineral metabolism, fibroblast growth factor 23 (FGF-23), total antioxidant capacity, and inflammatory markers has not been performed previously. In this study, we evaluated the effects of renal diet on mineral metabolism, oxidative stress and inflammation in dogs with stage 3 or 4 of chronic kidney disease (CKD). Body condition score (BCS), muscle condition score (MCS), serum biochemical profile, ionized calcium (i-Ca), total calcium (t-Ca), phosphorus (P), urea, creatinine, parathyroid hormone (PTH), FGF-23, interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α) and total antioxidant capacity (TAC) were measured at baseline (T0) and after 6 months of dietary treatment (T6). Serum urea, P, t-Ca, i-Ca, PTH, FGF-23, IL-6, IL-10, TNF-α and TAC measurements did not differ between T0 and T6. Serum creatinine (SCr) was increased at T6 and serum PTH concentrations were positively correlated with serum SCr and urea. i-Ca was negatively correlated with urea and serum phosphorus was positively correlated with FGF-23. Urea and creatinine were positively correlated. The combination of renal diet and support treatment over 6 months in dogs with CKD stage 3 or 4 was effective in controlling uremia, acid-base balance, blood pressure, total antioxidant capacity, and inflammatory cytokine levels and in maintaining BCS and MCS.
AB - An integrated study on the effect of renal diet on mineral metabolism, fibroblast growth factor 23 (FGF-23), total antioxidant capacity, and inflammatory markers has not been performed previously. In this study, we evaluated the effects of renal diet on mineral metabolism, oxidative stress and inflammation in dogs with stage 3 or 4 of chronic kidney disease (CKD). Body condition score (BCS), muscle condition score (MCS), serum biochemical profile, ionized calcium (i-Ca), total calcium (t-Ca), phosphorus (P), urea, creatinine, parathyroid hormone (PTH), FGF-23, interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α) and total antioxidant capacity (TAC) were measured at baseline (T0) and after 6 months of dietary treatment (T6). Serum urea, P, t-Ca, i-Ca, PTH, FGF-23, IL-6, IL-10, TNF-α and TAC measurements did not differ between T0 and T6. Serum creatinine (SCr) was increased at T6 and serum PTH concentrations were positively correlated with serum SCr and urea. i-Ca was negatively correlated with urea and serum phosphorus was positively correlated with FGF-23. Urea and creatinine were positively correlated. The combination of renal diet and support treatment over 6 months in dogs with CKD stage 3 or 4 was effective in controlling uremia, acid-base balance, blood pressure, total antioxidant capacity, and inflammatory cytokine levels and in maintaining BCS and MCS.
KW - Canine
KW - Inflammation
KW - Oxidative stress
KW - Secondary renal hyperparathyroidism
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U2 - 10.3390/toxins12010003
DO - 10.3390/toxins12010003
M3 - Article
C2 - 31861622
AN - SCOPUS:85077001576
SN - 2072-6651
VL - 12
JO - Toxins
JF - Toxins
IS - 1
M1 - 03
ER -