Evaluation of chitosan/biphasic calcium phosphate scaffolds for maxillofacial bone tissue engineering

Aylin Sendemir Urkmez, Sherrie G. Clark, Matthew B. Wheeler, Michael S. Goldwasser, Russell D. Jamison

Research output: Contribution to journalArticlepeer-review

Abstract

Porous, 30 chitosan/biphasic calcium phosphate (BCP) scaffolds were used to prepare tissue engineering constructs for maxillofacial bone tissue reconstruction. Mesenchymal stem cells (MSC's) were seeded and cultured on clinically relevant sized scaffolds. In vitro engineered constructs facilitated the healing of mandibular defects in pigs if accompanied with delivery of basic fibroblast growth factor (bFGF).

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalMacromolecular Symposia
Volume269
Issue number1
DOIs
StatePublished - Aug 1 2008

Keywords

  • Biomaterials
  • Biphasic calcium phosphate (BCP)
  • Bone tissue engineering
  • Chitosan
  • Scaffold

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Condensed Matter Physics

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