Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors

B. Hammond, B. S. Katzenellenbogen, N. Krauthammer, J. McConnell

Research output: Contribution to journalArticle

Abstract

The chlorinated insecticide chlordecone (Kepone) interacts with the estrogen receptor system in the rat uterus in vitro and in vivo. It competes with estradiol for binding to the cytoplasmic receptor in vitro and also induces nuclear accumulaton of estrogen receptor sites in uteri in vitro. When injected into immature rats, chlordecone translocates estrogen receptor sites to the uterine nucleus, increases uterine weight, and stimulates the synthesis of the progesterone receptor, an estrogen receptor-mediated process. Its slow onset of action but prolonged duration of interaction with estrogen receptor and stimulation of uterine weight gain and progesterone receptor synthesis indicates that, although it has an affinity for receptor only 0.01-0.04% that of estradiol, its considerable estrogenic activity may likely be derived from its long half-life and bioaccumulative character.

Original languageEnglish (US)
Pages (from-to)6641-6645
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number12
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • General

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