Estrogen regulates the synthesis of the egg yolk precursor protein, vitellogenin, by causing both a 20-60-fold increase in the absolute rate of total nuclear RNA synthesis and a selective increase of at least several thousand fold in the absolute rate of vitellogenin gene transcription. Vitellogenin gene transcription is undetectable in unstimulated and withdrawn Xenopus laevis liver cells and in cultured Xenopus kidney cell allowing us to set a very low upper limit (<1 transcript/vitellogenin gene/day) on potential basal rates of vitellogenin gene transcription. The elevated rates of vitellogenin mRNA accumulation previously observed during restimulation of withdrawn liver cells (secondary estrogen stimulation) appear to be due to an increased rate of vitellogenin gene transcription.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Biological Chemistry|
|State||Published - 1983|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology