TY - JOUR
T1 - Estrogen receptors alpha (ERα) and beta (ERβ)
T2 - Subtype-selective ligands and clinical potential
AU - Paterni, Ilaria
AU - Granchi, Carlotta
AU - Katzenellenbogen, John A.
AU - Minutolo, Filippo
N1 - Funding Information:
Intramural funding support from the University of Pisa (to F.M.) is gratefully acknowledged. Support from the National Institutes of Health (PHS R01CA025836 and R01DK015556 , to J.A.K.) is gratefully acknowledged.
Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.
AB - Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.
UR - http://www.scopus.com/inward/record.url?scp=84908672989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908672989&partnerID=8YFLogxK
U2 - 10.1016/j.steroids.2014.06.012
DO - 10.1016/j.steroids.2014.06.012
M3 - Review article
C2 - 24971815
AN - SCOPUS:84908672989
SN - 0039-128X
VL - 90
SP - 13
EP - 29
JO - Steroids
JF - Steroids
ER -