Estrogen receptor gets a grip on RNA

Benita S. Katzenellenbogen

doi:10.1016/j.cell.2021.09.012

Estrogen receptor gets a grip on RNA

Benita S. Katzenellenbogen

Molecular and Integrative Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.

Original language	English (US)
Pages (from-to)	5086-5088
Number of pages	3
Journal	Cell
Volume	184
Issue number	20
DOIs	https://doi.org/10.1016/j.cell.2021.09.012
State	Published - Sep 30 2021

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2021.09.012

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abstract = "The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.",

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note = "Funding Information: Research in the B.S.K. laboratory is supported by grants from the Breast Cancer Research Foundation (BCRF 20-083 and 20-084 ), the National Institutes of Health (NIH R01 CA220284 ), and the Landfield Cancer Research Fund. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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AB - The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.

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Estrogen receptor gets a grip on RNA

Abstract

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