Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (MS) and other demyelinating, inflammatory and neurodegenerative diseases

John A Katzenellenbogen (Inventor), Seema Kaushalya Tiwari-Woodruff (Inventor), Sung Hoon Kim (Inventor), Benita Katzenellenbogen (Inventor)

Research output: Patent

Abstract

4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.
Original languageEnglish (US)
U.S. patent number11673866
StatePublished - Jun 13 2023

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