Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Sean W. Fanning, Christopher G. Mayne, Venkatasubramanian Dharmarajan, Kathryn E. Carlson, Teresa A. Martin, Scott J. Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S. Katzenellenbogen, Emad Tajkhorshid, Patrick R. Griffin, Yang Shen, Sarat Chandarlapaty, John A. Katzenellenbogen, Geoffrey L. Greene

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Medicine & Life Sciences