Estrogen receptor-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues

Keyphrases

• Acetylene 100%
• Alkyl Nitriles 5%
• Alkyl Substituent 5%
• Aromatic Ring 11%
• Binding Affinity 11%
• Biological Function 5%
• Diarylpropionitrile 100%
• Estrogen Receptor 100%
• Estrogen Receptor 1 (ESR1) 100%
• Estrogen Receptor β 5%
• Fluorinated 5%
• Grouping Functions 5%
• Hydroxy Group 5%
• Ligand Structure 100%
• Linear Geometry 11%
• Low Affinity 5%
• Low Selectivity 5%
• Meso-2 5%
• Methyl 5%
• Nitrile Functionality 11%
• Nitrile Group 11%
• Nitriles 16%
• Novel Ligands 5%
• Optimal Combination 5%
• Ortho 5%
• P-hydroxyphenyl 44%
• Polarity Function 5%
• Preferential Binding 5%
• Propionitrile 33%
• Relative Binding Affinity 5%
• Relative Potency 5%
• Selective Ligands 100%
• Structure Function 5%
• Structure-activity Relationship Studies 100%
• Substituent Group 5%
• Subtype Selectivity 5%
• Succinonitrile 11%
• Transcription Assay 5%
• α-selective 5%
• α-Selectivity 5%
• α1-adrenoceptor 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Alkyl Group 5%
• Alpha Adrenergic Receptor 5%
• Diarylpropionitrile 100%
• Estrogen Receptor 100%
• Estrogen Receptor Alpha 100%
• Estrogen Receptor Beta 5%
• Estrogens 11%
• Hydroxyl Group 5%
• Nitrile 38%
• Propionitrile 33%
• Structure Activity Relationship 100%