Estradiol is a potent protective, restorative, and trophic factor after brain injury

Candice M. Brown, Shotaro Suzuki, Karen A.B. Jelks, Phyllis M. Wise

Research output: Contribution to journalReview articlepeer-review


Estrogens are a group of pleiotropic steroid hormones that exhibit diverse mechanisms of action in multiple physiologic systems. Over the past 30 years, biomedical science has begun to appreciate that endogenous estrogens and their receptors display important roles beyond the reproductive system. Our growing appreciation of novel, nonreproductive functions for estrogens has fundamentally contributed to our knowledge of their role in human health and disease. Recent findings from the Women's Health Initiative have caused clinicians and scientists to question whether estrogens are protective factors or risk factors. In light of the dichotomy between basic science and clinical studies, this review will attempt to reconcile differences between them. We will focus on studies from our laboratory and others highlighting the beneficial properties of the most abundant endogenous estrogen, 17β-estradiol, using in vivo and in vitro models of cerebral ischemia and neuronal injury. These studies demonstrate that 17β-estradiol powerfully protects the brain using multiple molecular mechanisms that promote: (1) decreased cell death, (2) increased neurogenesis, (3) an enhancement of neurotrophic support, and (4) the suppression of proinflammatory pathways.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
JournalSeminars in Reproductive Medicine
Issue number3
StatePublished - May 2009
Externally publishedYes


  • Cerebral ischemia
  • Estradiol
  • Estrogen therapy
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)


Dive into the research topics of 'Estradiol is a potent protective, restorative, and trophic factor after brain injury'. Together they form a unique fingerprint.

Cite this