Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise, D. B. Dubal, M. E. Wilson, S. W. Rau

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

    Original languageEnglish (US)
    Pages (from-to)401-410
    Number of pages10
    JournalJournal of Neurocytology
    Volume29
    Issue number5-6
    DOIs
    StatePublished - 2000

    ASJC Scopus subject areas

    • Anatomy
    • Neuroscience(all)
    • Histology
    • Cell Biology

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