Estradiol: A protective and trophic factor in the brain

D. B. Dubal, M. E. Wilson, P. M. Wise

    Research output: Contribution to journalReview articlepeer-review


    In recent years our appreciation that estradiol is truly a pleiotropic hormone has grown dramatically. We will review the findings that suggest that estrogens may exert important non-reproductive actions on the brain. These studies provide important insights into the clinical effects of estrogen replacement therapy on age- and disease-related processes in the brain. We will also discuss the multiple cellular and molecular mechanisms that may underlie estradiol's neurotrophic and neuroprotective effects.

    Original languageEnglish (US)
    Pages (from-to)265-274
    Number of pages10
    JournalJournal of Alzheimer's Disease
    Issue number4-5
    StatePublished - 1999

    ASJC Scopus subject areas

    • General Neuroscience
    • Clinical Psychology
    • Geriatrics and Gerontology
    • Psychiatry and Mental health


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