Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

Michael F. Henry, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible β-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

Original languageEnglish (US)
Pages (from-to)843-849
Number of pages7
JournalJournal of Molecular Biology
Volume222
Issue number4
DOIs
StatePublished - Dec 20 1991

Keywords

  • DNA binding protein
  • E. coli
  • fadR
  • fatty acid synthesis
  • transcription factor

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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