Keyphrases
Proton Transfer
100%
Hydride Transfer
100%
Temporal Order
100%
Escherichia Coli Dihydrofolate Reductase
100%
Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
75%
Ternary Complex
50%
Active Sites
25%
Water Molecule
25%
Temperature-independent
25%
Protonation
25%
Enzyme Catalysis
25%
Conversion Rate
25%
Nicotinamide Cofactor
25%
Overall Rate
25%
Binding Residues
25%
Effect Study
25%
Kinetic Isotope Effect
25%
Synergistic Role
25%
Stepwise Mechanism
25%
Complex Enzyme
25%
PH-independent
25%
Dihydrofolate
25%
Tetrahydrofolate
25%
Hydride Transfer Reactions
25%
Biochemistry, Genetics and Molecular Biology
Active Site
100%
Enzyme
100%
Escherichia coli
100%
Ternary Complex
100%
Dihydrofolate Reductase
100%
Proton Transport
50%
Static Electricity
50%
Protonation
50%
Kinetic Isotope Effect
50%
Nicotinamide
50%
Enzyme Catalysis
50%
Tetrahydrofolate
50%
Chemistry
NADPH
100%
Dihydrofolates
100%
Transfer Reaction
33%
Proton Transfer
33%
Cofactor
33%
Nicotinamide
33%
Kinetic Isotope Effect
33%
Catalysis
33%
Tetrahydrofolate
33%
Pharmacology, Toxicology and Pharmaceutical Science
Escherichia coli
100%
Reduced Nicotinamide Adenine Dinucleotide Phosphate
100%
Dihydrofolate Reductase
100%
Nicotinamide
33%
Dihydrofolic Acid
33%
Tetrahydrofolic Acid
33%