To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.
|Original language||English (US)|
|Number of pages||6|
|Journal||Applied and environmental microbiology|
|State||Published - Sep 2008|
ASJC Scopus subject areas
- Food Science
- Applied Microbiology and Biotechnology