Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model

Weiping Zhang; Donald C. Robertson; Chengxian Zhang; Wei Bai; Mojun Zhao; David H. Francis

doi:10.1128/AEM.00893-08

Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model

Weiping Zhang, Donald C. Robertson, Chengxian Zhang, Wei Bai, Mojun Zhao, David H. Francis

Research output: Contribution to journal › Article › peer-review

Abstract

To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.

Original language	English (US)
Pages (from-to)	5832-5837
Number of pages	6
Journal	Applied and environmental microbiology
Volume	74
Issue number	18
DOIs	https://doi.org/10.1128/AEM.00893-08
State	Published - Sep 2008
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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10.1128/AEM.00893-08

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abstract = "To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.",

author = "Weiping Zhang and Robertson, {Donald C.} and Chengxian Zhang and Wei Bai and Mojun Zhao and Francis, {David H.}",

year = "2008",

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AU - Zhang, Weiping

AU - Robertson, Donald C.

AU - Zhang, Chengxian

AU - Bai, Wei

AU - Zhao, Mojun

AU - Francis, David H.

PY - 2008/9

Y1 - 2008/9

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AB - To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.

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ER -

Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model

Abstract

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