Error catastrophe and phase transition in the empirical fitness landscape of HIV

Gregory R. Hart, Andrew L. Ferguson

Research output: Contribution to journalArticlepeer-review

Abstract

We have translated clinical sequence databases of the p6 HIV protein into an empirical fitness landscape quantifying viral replicative capacity as a function of the amino acid sequence. We show that the viral population resides close to a phase transition in sequence space corresponding to an "error catastrophe" beyond which there is lethal accumulation of mutations. Our model predicts that the phase transition may be induced by drug therapies that elevate the mutation rate, or by forcing mutations at particular amino acids. Applying immune pressure to any combination of killer T-cell targets cannot induce the transition, providing a rationale for why the viral protein can exist close to the error catastrophe without sustaining fatal fitness penalties due to adaptive immunity.

Original languageEnglish (US)
Article number032705
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume91
Issue number3
DOIs
StatePublished - Mar 10 2015

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Error catastrophe and phase transition in the empirical fitness landscape of HIV'. Together they form a unique fingerprint.

Cite this