TY - JOUR
T1 - ERα-associated protein networks
AU - Schultz-Norton, Jennifer R.
AU - Ziegler, Yvonne S.
AU - Nardulli, Ann M.
N1 - Funding Information:
This work was supported by National Institutes of Health R01 Grant DK53884 (to A.M.N.). We are indebted to John Yates, whose laboratory identified the ERα-associated proteins, and thank B.J. Slater for technical assistance.
PY - 2011/4
Y1 - 2011/4
N2 - Estrogen receptor α (ERα) is a ligand-activated transcription factor that, upon binding hormone, interacts with specific recognition sequences in DNA. An extensive body of literature has documented the association of individual regulatory proteins with ERα. It has recently become apparent that, instead of simply recruiting individual proteins, ERα recruits interconnected networks of proteins with discrete activities that play crucial roles in maintaining the structure and function of the receptor, stabilizing the receptor-DNA interaction, influencing estrogen-responsive gene expression, and repairing misfolded proteins and damaged DNA. Together these studies suggest that the DNA-bound ERα serves as a nucleating factor for the recruitment of protein complexes involved in key processes including the oxidative stress response, DNA repair, and transcription regulation.
AB - Estrogen receptor α (ERα) is a ligand-activated transcription factor that, upon binding hormone, interacts with specific recognition sequences in DNA. An extensive body of literature has documented the association of individual regulatory proteins with ERα. It has recently become apparent that, instead of simply recruiting individual proteins, ERα recruits interconnected networks of proteins with discrete activities that play crucial roles in maintaining the structure and function of the receptor, stabilizing the receptor-DNA interaction, influencing estrogen-responsive gene expression, and repairing misfolded proteins and damaged DNA. Together these studies suggest that the DNA-bound ERα serves as a nucleating factor for the recruitment of protein complexes involved in key processes including the oxidative stress response, DNA repair, and transcription regulation.
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U2 - 10.1016/j.tem.2010.11.005
DO - 10.1016/j.tem.2010.11.005
M3 - Review article
C2 - 21371903
AN - SCOPUS:79953164697
SN - 1043-2760
VL - 22
SP - 124
EP - 129
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -