ERα-associated protein networks

Jennifer R. Schultz-Norton, Yvonne S. Ziegler, Ann M. Nardulli

Research output: Contribution to journalReview articlepeer-review


Estrogen receptor α (ERα) is a ligand-activated transcription factor that, upon binding hormone, interacts with specific recognition sequences in DNA. An extensive body of literature has documented the association of individual regulatory proteins with ERα. It has recently become apparent that, instead of simply recruiting individual proteins, ERα recruits interconnected networks of proteins with discrete activities that play crucial roles in maintaining the structure and function of the receptor, stabilizing the receptor-DNA interaction, influencing estrogen-responsive gene expression, and repairing misfolded proteins and damaged DNA. Together these studies suggest that the DNA-bound ERα serves as a nucleating factor for the recruitment of protein complexes involved in key processes including the oxidative stress response, DNA repair, and transcription regulation.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number4
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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