@article{5b4ef3da514c462ea6042ca5e639f5ab,
title = "(±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth",
abstract = "Equol (EQ) is a prominent microbial metabolite of the soy isoflavone, daidzein, with estrogen-like properties. The major soy isoflavone, genistein (GEN), stimulated growth of estrogen-dependent breast cancer (EDBC) cells in vitro and tumor growth in vivo but EQ did not. To understand possible interactions of EQ and GEN on EDBC, EQ was used with GEN in combination in vitro and in vivo. Effects of EQ, GEN and EQ + GEN were evaluated using MCF-7 and T47D EDBC. Ovariectomized athymic mice were used as a model for in vivo tumor growth. Dietary EQ had no effect on MCF-7 tumor growth and the absence of effect was confirmed using a T47D EDBC in vivo model. EQ alone or in combination with GEN increased EDBC cell proliferation in vitro. EQ alone neither stimulated EDBC tumor growth in vivo at various doses nor suppressed tumor growth induced by dietary GEN. In summary, EQ has similar estrogenic effect as GEN in vitro but does not interact with GEN on EDBC tumor growth. Based on the evidence presented here, dietary EQ is unlikely to have estrogenic effects in vivo.",
keywords = "Equol, Genistein, MCF-7, T47D",
author = "Hauxin Song and Hughes, {Jennifer R.} and Turner, {Russell T.} and Iwaniec, {Urszula T.} and Doerge, {Daniel R.} and Helferich, {William G.}",
note = "Funding Information: This work was supported by Grant Number 5P01AG024387 (WGH) from the National Center for Complementary and Integrative Health (NCCIH) , the Office of Dietary Supplements (ODS) and the National Cancer Institute (NCI) . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the U.S. Food and Drug Administration , NCCIH , ODS , NCI or the National Institutes of Health ; Grant Number P50AT006268 (WGH) from the National Center for Complementary and Integrative Health (NCCIH) , the Office of Dietary Supplements (ODS) and the National Cancer Institute (NCI) ; and NIEHS Training Grant T32 ES07326 (JRH). Funding Information: This work was supported by Grant Number 5P01AG024387 (WGH) from the National Center for Complementary and Integrative Health (NCCIH), the Office of Dietary Supplements (ODS) and the National Cancer Institute (NCI). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the U.S. Food and Drug Administration, NCCIH, ODS, NCI or the National Institutes of Health; Grant Number P50AT006268 (WGH) from the National Center for Complementary and Integrative Health (NCCIH), the Office of Dietary Supplements (ODS) and the National Cancer Institute (NCI); and NIEHS Training Grant T32 ES07326 (JRH). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = feb,
doi = "10.1016/j.fct.2019.110979",
language = "English (US)",
volume = "136",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
}