Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

Diego Hernández-Saavedra, Laura Moody, Guanying Bianca Xu, Hong Chen, Yuan-Xiang Pan

Research output: Contribution to journalReview article

Abstract

Chronic caloric restriction (CR) without malnutrition is known to affect different cellular processes such as stem cell function, cell senescence, inflammation, and metabolism. Despite the differences in the implementation of CR, the reduction of calories produces a widespread beneficial effect in noncommunicable chronic diseases, which can be explained by improvements in immuno-metabolic adaptation. Cellular adaptation that occurs in response to dietary patterns can be explained by alterations in epigenetic mechanisms such as DNA methylation, histone modifications, and microRNA. In this review, we define these modifications and systematically summarize the current evidence related to CR and the epigenome. We then explain the significance of genome-wide epigenetic modifications in the context of disease development. Although substantial evidence exists for the widespread effect of CR on longevity, there is no consensus regarding the epigenetic regulations of the underlying cellularmechanisms that lead to improved health. We provide compelling evidence that CR produces long-lasting epigenetic effects that mediate expression of genes related to immuno-metabolic processes. Epigenetic reprogramming of the underlying chronic low-grade inflammation by CR can lead to immunometabolic adaptations that enhance quality of life, extend lifespan, and delay chronic disease onset.

Original languageEnglish (US)
Pages (from-to)520-536
Number of pages17
JournalAdvances in Nutrition
Volume10
Issue number3
DOIs
StatePublished - May 1 2019

Fingerprint

Caloric Restriction
Epigenomics
epigenetics
inflammation
Inflammation
metabolism
chronic diseases
Chronic Disease
Histone Code
DNA methylation
microRNA
quality of life
eating habits
histones
Cell Aging
malnutrition
DNA Methylation
stem cells
MicroRNAs
Malnutrition

Keywords

  • DNA methylation
  • Dietary restriction
  • Energy intake
  • Histone acetylation
  • Microrna
  • Sirtuin

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction. / Hernández-Saavedra, Diego; Moody, Laura; Xu, Guanying Bianca; Chen, Hong; Pan, Yuan-Xiang.

In: Advances in Nutrition, Vol. 10, No. 3, 01.05.2019, p. 520-536.

Research output: Contribution to journalReview article

Hernández-Saavedra, Diego ; Moody, Laura ; Xu, Guanying Bianca ; Chen, Hong ; Pan, Yuan-Xiang. / Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction. In: Advances in Nutrition. 2019 ; Vol. 10, No. 3. pp. 520-536.
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