Epigenetic profiles associated with major depression in the human brain

Angela C. Bustamante, Don L. Armstrong, Monica Uddin

Research output: Contribution to journalArticlepeer-review


We conducted an epigenome-wide association study of Major Depressive Disorder (MDD) in brain-derived DNA using two analytic approaches. DNA methylation data (GSE41826) was used in differential methylation (DM) analyses controlling for age, sex, suicide status, and post-mortem interval; and in weighted gene co-methylation network analyses (WGCNA) in probes mapping to transcription start sites. No probes in the DM analysis survived FDR correction. Nominally significant DM probes were enriched in synaptic function-related genes. WGCNA revealed one module correlated with MDD, enriched in genes associated with mitochondrial function. DM and WGCNA both showed enrichment of genes involved in transcription and DNA binding.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalPsychiatry Research
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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