Abstract
Colon and rectal cancer (colorectal -cancer, CRC) is the third most common cancer worldwide. Deaths from CRC account for around 8% of all cancer deaths, making it the fourth most common cause of death from cancer. The high mortality rate of colon cancer is mainly attributable to its metastasis. Efforts have been made to identify metastasis suppressor genes, which encode proteins responsible for inhibiting the metastasis but not suppressing the growth of primary tumors. Studies on metastasis suppressor genes demonstrated that epigenetic modifications, such as DNA promoter methylation and histone modification, play crucial roles in regulating the expression of many metastasis suppressor genes, which indicates the association between aberrant epigenetic alterations and cancer metastasis. This review will focus on the recent findings regarding metastasis suppressors regulated by epigeneticmodifications, particularly DNA methylation and histone modification, in CRC metastasis. Also, we will discuss recent progress on the suppression of CRC metastasis by genistein, a soy isoflavone, with a focus on epigenetic mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 849-852 |
| Number of pages | 4 |
| Journal | Epigenetics |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2011 |
Fingerprint
Keywords
- Cell adhesion
- Colorectal cancer
- E-cadherin
- Metastasis suppressor
- NDRG1
- Nm23
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
Cite this
Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis. / Li, Qian; Chen, Hong.
In: Epigenetics, Vol. 6, No. 7, 07.2011, p. 849-852.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis
AU - Li, Qian
AU - Chen, Hong
PY - 2011/7
Y1 - 2011/7
N2 - Colon and rectal cancer (colorectal -cancer, CRC) is the third most common cancer worldwide. Deaths from CRC account for around 8% of all cancer deaths, making it the fourth most common cause of death from cancer. The high mortality rate of colon cancer is mainly attributable to its metastasis. Efforts have been made to identify metastasis suppressor genes, which encode proteins responsible for inhibiting the metastasis but not suppressing the growth of primary tumors. Studies on metastasis suppressor genes demonstrated that epigenetic modifications, such as DNA promoter methylation and histone modification, play crucial roles in regulating the expression of many metastasis suppressor genes, which indicates the association between aberrant epigenetic alterations and cancer metastasis. This review will focus on the recent findings regarding metastasis suppressors regulated by epigeneticmodifications, particularly DNA methylation and histone modification, in CRC metastasis. Also, we will discuss recent progress on the suppression of CRC metastasis by genistein, a soy isoflavone, with a focus on epigenetic mechanisms.
AB - Colon and rectal cancer (colorectal -cancer, CRC) is the third most common cancer worldwide. Deaths from CRC account for around 8% of all cancer deaths, making it the fourth most common cause of death from cancer. The high mortality rate of colon cancer is mainly attributable to its metastasis. Efforts have been made to identify metastasis suppressor genes, which encode proteins responsible for inhibiting the metastasis but not suppressing the growth of primary tumors. Studies on metastasis suppressor genes demonstrated that epigenetic modifications, such as DNA promoter methylation and histone modification, play crucial roles in regulating the expression of many metastasis suppressor genes, which indicates the association between aberrant epigenetic alterations and cancer metastasis. This review will focus on the recent findings regarding metastasis suppressors regulated by epigeneticmodifications, particularly DNA methylation and histone modification, in CRC metastasis. Also, we will discuss recent progress on the suppression of CRC metastasis by genistein, a soy isoflavone, with a focus on epigenetic mechanisms.
KW - Cell adhesion
KW - Colorectal cancer
KW - E-cadherin
KW - Metastasis suppressor
KW - NDRG1
KW - Nm23
UR - http://www.scopus.com/inward/record.url?scp=79960113856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960113856&partnerID=8YFLogxK
U2 - 10.4161/epi.6.7.16314
DO - 10.4161/epi.6.7.16314
M3 - Article
C2 - 21758003
AN - SCOPUS:79960113856
VL - 6
SP - 849
EP - 852
JO - Epigenetics
JF - Epigenetics
SN - 1559-2294
IS - 7
ER -