Epigenetic Epidemiology of Psychiatric Disorders

Monica Uddin, Angela Bustamante, Satoshi Toyokawa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epigenetic epidemiology is in its relative infancy, and this is no less true for epigenetic studies of psychiatric disorders. Here we attempt to provide a non-exhaustive overview of this field, summarizing the current state of the literature while acknowledging the particular challenges associated with psychiatric epigenetic epidemiology studies. Specifically, we address the challenges associated with causal inference in epigenetic epidemiology, provide specific examples of psychiatric epigenetic epidemiology studies and study designs that have been reported to date, discuss factors that should be considered in designing robust psychiatric epigenetic epidemiology studies, highlight the importance of a life-course perspective, and offer an outlook on future research in this burgeoning field.

Original languageEnglish (US)
Title of host publicationEpigenetics in Psychiatry
PublisherElsevier Inc.
Pages101-127
Number of pages27
ISBN (Electronic)9780124171343
ISBN (Print)9780124171145
DOIs
StatePublished - Jun 20 2014
Externally publishedYes

Keywords

  • Birth cohort
  • Case-control design
  • Causal inference
  • Effect size
  • Epigenome-wide association study
  • Longitudinal study
  • Population research
  • Tissue specificity

ASJC Scopus subject areas

  • General Medicine

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