TY - JOUR
T1 - Epidemiological analysis of respiratory viral etiology for influenza-like illness during 2010 in Zhuhai, China
AU - Li, Hongxia
AU - Wei, Quande
AU - Tan, Aijun
AU - Wang, Leyi
N1 - Funding Information:
We would like to express our gratitude to Lisha Zhu for assistance with meteorological data. We thank Yong Tian for laboratory support in the execution of the study. We thank Christina Quigley for critical reviews of the manuscript. This study was supported in part by a Chinese Center for Disease Control and Prevention (CDC) initiated project to identify influenza virus infection during 2010 and funded by the Zhuhai Health Bureau (grant number 2010092).
PY - 2013
Y1 - 2013
N2 - Background: Influenza-like illnesses (ILI), a subset of acute respiratory infections (ARI), are a significant source of morbidity and mortality worldwide. ILI can be caused by numerous pathogens, however; there is limited information on the etiology and epidemiology of ILI in China. Methods. We performed a one-year surveillance study (2010) of viral etiology causing ILI and investigated the influence of climate on outbreaks of ILI attributed to viruses at the Outpatient Department of Zhuhai Municipal People's Hospital in Zhuhai, China. Results: Of the 337,272 outpatients who sought attention in the Outpatient Department of Zhuhai Municipal People's Hospital in 2010, 3,747 (1.11%) presented with ILI. Of these patients presenting with ILI, 24.66% (924/3,747) had available samples and were enrolled in this study. At least one respiratory virus was identified in 411 patients (44.48%) and 42 (4.55%) were co-infected with two viruses. In patients co-infected with two viruses, respiratory syncytial virus (RSV) was detected in 50% (21/42). Among common viral pathogens detected, significant differences in age distributions were observed in seasonal influenza virus A (sFulA, H3N2) and B (sFluB), pandemic H1N1 2009 influenza viruses (H1N1pdm09), RSV, and adenovirus (ADV). Infections with sFluA (H3N2), sFluB, RSV, and human metapneumovirus (HMPV) had characteristic seasonal patterns. The incidences of sFluA (H3N2), ADV, and RSV correlated with air temperature. Alternatively, the incidence of sFluB correlated with relative air humidity. Conclusions: These results demonstrate that a wide range of respiratory viral pathogens are circulating in Zhuhai city. This information needs to be considered by clinicians when treating patients presenting with ILI.
AB - Background: Influenza-like illnesses (ILI), a subset of acute respiratory infections (ARI), are a significant source of morbidity and mortality worldwide. ILI can be caused by numerous pathogens, however; there is limited information on the etiology and epidemiology of ILI in China. Methods. We performed a one-year surveillance study (2010) of viral etiology causing ILI and investigated the influence of climate on outbreaks of ILI attributed to viruses at the Outpatient Department of Zhuhai Municipal People's Hospital in Zhuhai, China. Results: Of the 337,272 outpatients who sought attention in the Outpatient Department of Zhuhai Municipal People's Hospital in 2010, 3,747 (1.11%) presented with ILI. Of these patients presenting with ILI, 24.66% (924/3,747) had available samples and were enrolled in this study. At least one respiratory virus was identified in 411 patients (44.48%) and 42 (4.55%) were co-infected with two viruses. In patients co-infected with two viruses, respiratory syncytial virus (RSV) was detected in 50% (21/42). Among common viral pathogens detected, significant differences in age distributions were observed in seasonal influenza virus A (sFulA, H3N2) and B (sFluB), pandemic H1N1 2009 influenza viruses (H1N1pdm09), RSV, and adenovirus (ADV). Infections with sFluA (H3N2), sFluB, RSV, and human metapneumovirus (HMPV) had characteristic seasonal patterns. The incidences of sFluA (H3N2), ADV, and RSV correlated with air temperature. Alternatively, the incidence of sFluB correlated with relative air humidity. Conclusions: These results demonstrate that a wide range of respiratory viral pathogens are circulating in Zhuhai city. This information needs to be considered by clinicians when treating patients presenting with ILI.
KW - Epidemiological analysis
KW - Influenza-like illness (ILI)
KW - Meteorology
KW - Respiratory viral pathogens
UR - http://www.scopus.com/inward/record.url?scp=84877073758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877073758&partnerID=8YFLogxK
U2 - 10.1186/1743-422X-10-143
DO - 10.1186/1743-422X-10-143
M3 - Article
C2 - 23651577
AN - SCOPUS:84877073758
SN - 1743-422X
VL - 10
JO - Virology Journal
JF - Virology Journal
M1 - 143
ER -