Enzymology of influenza virus sialidase

Jefferson Chan; Andrew J. Bennet

doi:10.1007/978-3-7643-8927-7_3

Enzymology of influenza virus sialidase

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Influenza virus sialidase plays a key role in the infectious lifecycle of the virus. This chapter provides a discussion of the tools, such as linear free energy relationships and kinetic isotope effects, used in exploring enzyme mechanisms and an introduction to mechanistic aspects, including transition state analysis and whether the intermediate that follows the glycosylation TS, in retaining glycosidases, is an oxacarbenium ion or is covalently linked to the enzyme. A general discussion of microbial sialidase catalysis is provided, as well as an overview of the catalytic mechanism of influenza virus sialidases.

Original language	English (US)
Title of host publication	Influenza Virus Sialidase - A Drug Discovery Target
Publisher	Springer Basel
Pages	47-66
Number of pages	20
ISBN (Electronic)	9783764389277
ISBN (Print)	9783764389260
DOIs	https://doi.org/10.1007/978-3-7643-8927-7_3
State	Published - Jan 1 2012
Externally published	Yes

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ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chan, J., & Bennet, A. J. (2012). Enzymology of influenza virus sialidase. In Influenza Virus Sialidase - A Drug Discovery Target (pp. 47-66). Springer Basel. https://doi.org/10.1007/978-3-7643-8927-7_3

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Access to Document

10.1007/978-3-7643-8927-7_3