Enzymology of influenza virus sialidase

Jefferson Chan, Andrew J. Bennet

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Influenza virus sialidase plays a key role in the infectious lifecycle of the virus. This chapter provides a discussion of the tools, such as linear free energy relationships and kinetic isotope effects, used in exploring enzyme mechanisms and an introduction to mechanistic aspects, including transition state analysis and whether the intermediate that follows the glycosylation TS, in retaining glycosidases, is an oxacarbenium ion or is covalently linked to the enzyme. A general discussion of microbial sialidase catalysis is provided, as well as an overview of the catalytic mechanism of influenza virus sialidases.

Original languageEnglish (US)
Title of host publicationInfluenza Virus Sialidase - A Drug Discovery Target
PublisherSpringer Basel
Pages47-66
Number of pages20
ISBN (Electronic)9783764389277
ISBN (Print)9783764389260
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Chan, J., & Bennet, A. J. (2012). Enzymology of influenza virus sialidase. In Influenza Virus Sialidase - A Drug Discovery Target (pp. 47-66). Springer Basel. https://doi.org/10.1007/978-3-7643-8927-7_3