Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

Chris M. McGinley, Wilfred A. van der Donk

Research output: Contribution to journalArticlepeer-review


The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.

Original languageEnglish (US)
Pages (from-to)2843-2846
Number of pages4
JournalChemical Communications
Issue number23
StatePublished - 2003

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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