Abstract
Constraints on phenotypic variation limit the capacity of organisms to adapt to the multiple selection pressures encountered in natural environments. To better understand evolutionary dynamics in this context, we select Escherichia coli for faster migration through a porous environment, a process which depends on both motility and growth. We find that a trade- off between swimming speed and growth rate constrains the evolution of faster migration. Evolving faster migration in rich medium results in slow growth and fast swimming, while evolution in minimal medium results in fast growth and slow swimming. In each condition parallel genomic evolution drives adaptation through different mutations. We show that the trade-off is mediated by antagonistic pleiotropy through mutations that affect negative regulation. A model of the evolutionary process shows that the genetic capacity of an organism to vary traits can qualitatively depend on its environment, which in turn alters its evolutionary trajectory.
Original language | English (US) |
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Article number | e24669 |
Journal | eLife |
Volume | 6 |
DOIs | |
State | Published - Mar 27 2017 |
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
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Sample video and supplementary code for cell tracking
Mickalide, H. (Creator), Fraebel, D. T. (Creator) & Kuehn, S. (Creator), University of Illinois Urbana-Champaign, Mar 7 2017
DOI: 10.13012/B2IDB-4912922_V2
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