Enteric MRI contrast agents: Comparative study of five potential agents in humans

Roger P. Tart, King C.P. Li, Brett L. Storm, Richard J. Rolfes, Peter G.P. Ang

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the effectiveness of 1 mM Geritol, 12% corn oil emulsion, Kaolin-pectin, single contrast oral barium sulfate, and effervescent granules as enteric magnetic resonance imaging (MRI) contrast agents. Five volunteers were recruited. Each volunteer ingested for examinations, separated by at least one week, either 500 ml of each of the liquid preparations or two packets of the CO2 granules (producing 400 ml of CO2 per packet). Abdominal MR images were then obtained using a 1.5 T Magnetom imager and SE 550/22, SE 2000/45/90 and FISP 40/18/40° pulse sequences. The oil emulsions were best tolerated. Barium sulfate caused the greatest amount of nausea, followed by Geritol and Kaolin-pectin. With FISP 40/18/40°, 60%-80% of the small bowel was well delineated using oil emulsion, Kaolin-pectin, or barium sulfate. We conclude that oil emulsion was by far the best enteric MR contrast agent in our study. Good delineation of the small bowel and pancreas can be achieved using oil emulsion and gradient echo pulse sequences. The lack of side-effects and the excellent taste make it highly acceptable to human subjects.

Original languageEnglish (US)
Pages (from-to)559-568
Number of pages10
JournalMagnetic Resonance Imaging
Volume9
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Contrast agents
  • Gastrointestinal
  • Gradient echo
  • Magnetic resonance
  • Oil emuslsion

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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