Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

M. B. Levanti; I. Esteban; E. Ciriaco; P. Pérez-Piñera; R. Cabo; O. García-Suarez; B. Pardo; I. Silos-Santiago; J. Cobo; J. A. Vega

doi:10.1016/j.neulet.2009.02.051

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

M. B. Levanti, I. Esteban, E. Ciriaco, P. Pérez-Piñera, R. Cabo, O. García-Suarez, B. Pardo, I. Silos-Santiago, J. Cobo, J. A. Vega

Research output: Contribution to journal › Article › peer-review

Abstract

The embryonic development of the enteric nervous system (ENS) from neural crest precursor cells requires neurotrophic signaling. Neurotrophins (NTs) are a family of growth factors that bind Trk receptors to signal diverse functions, including development and maintenance of different cell populations in the peripheral nervous system. In this study we investigated the expression and cell localization of TrkB, the high affinity receptor for brain-derived neurotrophic factor and NT-4, in the murine ENS using Western blot and immunohistochemistry. The results demonstrate that enteric glial cells within the ENS express full-length TrkB at all stages tested. The ENS of TrkB deficient mice have reduced expression of glial cell markers, and a disarrangement of glial cells and the plexular neuropil. These results strongly suggest TrkB has essential roles in the normal development and maintenance of glial cells in the ENS.

Original language	English (US)
Pages (from-to)	16-21
Number of pages	6
Journal	Neuroscience Letters
Volume	454
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2009.02.051
State	Published - Apr 17 2009
Externally published	Yes

Keywords

Enteric glial cells
Enteric nervous system
Neurotrophins
TrkB
TrkB deficient mice

ASJC Scopus subject areas

Neuroscience(all)

Online availability

10.1016/j.neulet.2009.02.051

Library availability

Discover UIUC Full Text

Cite this

@article{6de97b9c004a473a8b49f3b3cdc88151,

title = "Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development",

abstract = "The embryonic development of the enteric nervous system (ENS) from neural crest precursor cells requires neurotrophic signaling. Neurotrophins (NTs) are a family of growth factors that bind Trk receptors to signal diverse functions, including development and maintenance of different cell populations in the peripheral nervous system. In this study we investigated the expression and cell localization of TrkB, the high affinity receptor for brain-derived neurotrophic factor and NT-4, in the murine ENS using Western blot and immunohistochemistry. The results demonstrate that enteric glial cells within the ENS express full-length TrkB at all stages tested. The ENS of TrkB deficient mice have reduced expression of glial cell markers, and a disarrangement of glial cells and the plexular neuropil. These results strongly suggest TrkB has essential roles in the normal development and maintenance of glial cells in the ENS.",

keywords = "Enteric glial cells, Enteric nervous system, Neurotrophins, TrkB, TrkB deficient mice",

author = "Levanti, {M. B.} and I. Esteban and E. Ciriaco and P. P{\'e}rez-Pi{\~n}era and R. Cabo and O. Garc{\'i}a-Suarez and B. Pardo and I. Silos-Santiago and J. Cobo and Vega, {J. A.}",

year = "2009",

month = apr,

day = "17",

doi = "10.1016/j.neulet.2009.02.051",

language = "English (US)",

volume = "454",

pages = "16--21",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

AU - Levanti, M. B.

AU - Esteban, I.

AU - Ciriaco, E.

AU - Pérez-Piñera, P.

AU - Cabo, R.

AU - García-Suarez, O.

AU - Pardo, B.

AU - Silos-Santiago, I.

AU - Cobo, J.

AU - Vega, J. A.

PY - 2009/4/17

Y1 - 2009/4/17

N2 - The embryonic development of the enteric nervous system (ENS) from neural crest precursor cells requires neurotrophic signaling. Neurotrophins (NTs) are a family of growth factors that bind Trk receptors to signal diverse functions, including development and maintenance of different cell populations in the peripheral nervous system. In this study we investigated the expression and cell localization of TrkB, the high affinity receptor for brain-derived neurotrophic factor and NT-4, in the murine ENS using Western blot and immunohistochemistry. The results demonstrate that enteric glial cells within the ENS express full-length TrkB at all stages tested. The ENS of TrkB deficient mice have reduced expression of glial cell markers, and a disarrangement of glial cells and the plexular neuropil. These results strongly suggest TrkB has essential roles in the normal development and maintenance of glial cells in the ENS.

AB - The embryonic development of the enteric nervous system (ENS) from neural crest precursor cells requires neurotrophic signaling. Neurotrophins (NTs) are a family of growth factors that bind Trk receptors to signal diverse functions, including development and maintenance of different cell populations in the peripheral nervous system. In this study we investigated the expression and cell localization of TrkB, the high affinity receptor for brain-derived neurotrophic factor and NT-4, in the murine ENS using Western blot and immunohistochemistry. The results demonstrate that enteric glial cells within the ENS express full-length TrkB at all stages tested. The ENS of TrkB deficient mice have reduced expression of glial cell markers, and a disarrangement of glial cells and the plexular neuropil. These results strongly suggest TrkB has essential roles in the normal development and maintenance of glial cells in the ENS.

KW - Enteric glial cells

KW - Enteric nervous system

KW - Neurotrophins

KW - TrkB

KW - TrkB deficient mice

UR - http://www.scopus.com/inward/record.url?scp=62349087990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62349087990&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2009.02.051

DO - 10.1016/j.neulet.2009.02.051

M3 - Article

C2 - 19429046

AN - SCOPUS:62349087990

SN - 0304-3940

VL - 454

SP - 16

EP - 21

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this