Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles

Santosh K. Misra, Tor W. Jensen, Dipanjan Pan

Research output: Contribution to journalArticle

Abstract

We describe for the first time a therapeutic strategy to target stem-like cancer cells via STAT-3 modulation using a nanomedicine approach. Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. Niclocelles were found to selectively reduce the CD44+ stem cell population in C32 cells via STAT-3 modulation.

Original languageEnglish (US)
Pages (from-to)7127-7132
Number of pages6
JournalNanoscale
Volume7
Issue number16
DOIs
StatePublished - Apr 28 2015

ASJC Scopus subject areas

  • Materials Science(all)

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