Abstract
We describe for the first time a therapeutic strategy to target stem-like cancer cells via STAT-3 modulation using a nanomedicine approach. Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. Niclocelles were found to selectively reduce the CD44+ stem cell population in C32 cells via STAT-3 modulation.
Original language | English (US) |
---|---|
Pages (from-to) | 7127-7132 |
Number of pages | 6 |
Journal | Nanoscale |
Volume | 7 |
Issue number | 16 |
DOIs | |
State | Published - Apr 28 2015 |
ASJC Scopus subject areas
- General Materials Science